SCHEMBL4552467

SCHEMBL4552467

CC(=O)Nc1cccc(F)c1B(O)O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.46
HPGD P15428 2/20 0.46
KDM4E B2RXH2 3/20 0.44
HDAC1 Q13547 2/20 0.44
LMNA P02545 1/20 0.44
RAB9A P51151 5/20 0.43
NPC1 O15118 3/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
GAA P10253 2/20 0.42
STAT1 P42224 1/20 0.42
MAOA P21397 1/20 0.41
CYP2C19 P33261 2/20 0.41
POLB P06746 1/20 0.41
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
HDAC6 Q9UBN7 1/20 0.41
HSD17B10 Q99714 1/20 0.41
MAPK1 P28482 1/20 0.40
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3782804 0.87 ALDH1A1 (0.53) ALDH1A1HPGDKDM4ERAB9ANPC1
SCHEMBL30368335 0.78 ALDH1A1 (0.52) ALDH1A1HPGDKDM4EHDAC1LMNA
SCHEMBL1430696 0.78 ALDH1A1 (0.52) ALDH1A1HPGDKDM4EHDAC1LMNA
SCHEMBL1430533 0.77 RAB9A (0.69) ALDH1A1HPGDKDM4ELMNARAB9A
SCHEMBL29408738 0.77 RAB9A (0.69) ALDH1A1HPGDKDM4ELMNARAB9A
SCHEMBL863826 0.77 SMN1; SMN2 (0.61) ALDH1A1HPGDKDM4EHDAC1LMNA
SCHEMBL30002532 0.77 SMN1; SMN2 (0.61) ALDH1A1HPGDKDM4EHDAC1LMNA
SCHEMBL6379676 0.77 ALDH1A1 (0.50) ALDH1A1HPGDKDM4EHDAC1LMNA
SCHEMBL13414540 0.75 ALDH1A1 (0.57) ALDH1A1HPGDKDM4ERAB9ANPC1
SCHEMBL12475810 0.75 ALDH1A1 (0.48) ALDH1A1HPGDKDM4EHDAC1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8241574-B2 Ophthalmic device comprising a holographic sensor SMART HOLOGRAMS LIMITED (GB) 2012-08-14 US disclosed
US-20120107944-A1 Holographic Sensor LOWE CHRISTOPHER ROBIN (GB) 2012-05-03 US disclosed
US-20110286064-A1 OPHTHALMIC DEVICE COMPRISING A HOLOGRAPHIC SENSOR BURLES BARRY (GB) 2011-11-24 US disclosed
US-8048680-B2 Holographic sensor SMART HOLOGRAMS LIMITED (GB) 2011-11-01 US disclosed
US-8048680-B2 Holographic sensor SMART HOLOGRAMS LIMITED (GB) 2011-11-01 US disclosed
US-7998412-B2 Ophthalmic device comprising a holographic sensor SMART HOLOGRAMS LIMITED (GB) 2011-08-16 US disclosed
US-7998412-B2 Ophthalmic device comprising a holographic sensor SMART HOLOGRAMS LIMITED (GB) 2011-08-16 US disclosed
US-20090021697-A1 Ophthalmic Device Comprising a Holographic Sensor SMART HOLOGRAMS LIMITED (GB) 2009-01-22 US disclosed
US-20090021697-A1 Ophthalmic Device Comprising a Holographic Sensor SMART HOLOGRAMS LIMITED (GB) 2009-01-22 US disclosed