Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | CPB1 | P15086 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3451086 | 0.87 | SIGMAR1 (0.44) | SIGMAR1ALDH1A1USP2TSHRHSD17B10 | |
| SCHEMBL4563423 | 0.82 | SIGMAR1 (0.40) | SIGMAR1ALDH1A1USP2TSHRHSD17B10 | |
| SCHEMBL3801432 | 0.78 | SIGMAR1 (0.46) | SIGMAR1ALDH1A1USP2TSHRHSD17B10 | |
| SCHEMBL22467693 | 0.78 | SIGMAR1 (0.46) | SIGMAR1ALDH1A1USP2TSHRHSD17B10 | |
| SCHEMBL11590269 | 0.77 | SIGMAR1 (0.53) | SIGMAR1CHRNB2CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL8595770 | 0.77 | SLC6A2 (0.49) | SIGMAR1ALDH1A1USP2TSHRHSD17B10 | |
| SCHEMBL4563352 | 0.76 | GRM5 (0.36) | SIGMAR1ALDH1A1USP2TSHRHSD17B10 | |
| SCHEMBL28290160 | 0.75 | SIGMAR1 (0.44) | SIGMAR1ALDH1A1USP2TSHRHSD17B10 | |
| SCHEMBL8498078 | 0.75 | SIGMAR1 (0.44) | SIGMAR1ALDH1A1USP2TSHRHSD17B10 | |
| SCHEMBL15603465 | 0.73 | CHRNB2 (0.32) | CHRNB2CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090325964-A1 | Piperazine Metabotropic Glutamate Receptor 5 (MGLUR5) Negative Allosteric Modulators For Anxiety/Depression | WYETH (US) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325964-A1 | Piperazine Metabotropic Glutamate Receptor 5 (MGLUR5) Negative Allosteric Modulators For Anxiety/Depression | GRM5, GRIK5, GRM1 | SIGMAR1 413/4885ALDH1A1 3104/4885USP2 2570/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.