Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.44 |
| ▸ | CTSV | O60911 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSA | P10619 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.36 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4554107 | 0.89 | HDAC8 (0.45) | HDAC8CTSVCTSLCTSBCTSS | |
| SCHEMBL4553919 | 0.87 | AKT1 (0.38) | HDAC8CTSVCTSLCTSBCTSS | |
| SCHEMBL4384617 | 0.82 | HDAC8 (0.43) | HDAC8CTSVCTSLCTSBCTSS | |
| SCHEMBL4542689 | 0.80 | HDAC8 (0.39) | HDAC8CTSVCTSLCTSBCTSS | |
| SCHEMBL3329890 | 0.80 | HDAC8 (0.47) | HDAC8CTSVCTSLCTSBCTSS | |
| SCHEMBL4431729 | 0.80 | CCR1 (0.40) | HDAC8 | |
| SCHEMBL1682698 | 0.79 | HDAC8 (0.40) | HDAC8CTSVCTSLCTSBCTSS | |
| SCHEMBL3329755 | 0.79 | HDAC8 (0.43) | HDAC8CTSVCTSLCTSBCTSS | |
| SCHEMBL4554202 | 0.79 | CTSV (0.42) | HDAC8CTSVCTSLCTSBCTSS | |
| SCHEMBL4371338 | 0.78 | HDAC8 (0.40) | HDAC8CTSVCTSLCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134175-A1 | INHIBITORS OF AKT ACTIVITY | Smithkline Beecham Corporation (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008121786-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-09 | — | — | WO | disclosed |