Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 10/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4439796 | 0.85 | HDAC3 (0.38) | HDAC3HDAC1HDAC6KDM4EALDH1A1 | |
| SCHEMBL4552839 | 0.80 | HDAC8 (0.44) | HDAC8 | |
| SCHEMBL4374524 | 0.77 | ALDH1A1 (0.47) | CCR1ALDH1A1 | |
| SCHEMBL4583485 | 0.77 | ALDH1A1 (0.47) | CCR1ALDH1A1 | |
| SCHEMBL4582505 | 0.76 | HPGD (0.54) | ALDH1A1 | |
| SCHEMBL4375386 | 0.76 | ACKR3 (0.43) | HDAC3HDAC4HDAC1KDM4EALDH1A1 | |
| SCHEMBL4382189 | 0.76 | ACKR3 (0.43) | HDAC3HDAC4HDAC1KDM4EALDH1A1 | |
| SCHEMBL1682690 | 0.75 | GRM5 (0.43) | CCR1HDAC1HDAC8HDAC6 | |
| SCHEMBL4441483 | 0.75 | MME (0.46) | HDAC3HDAC4HDAC1HDAC8HDAC6 | |
| SCHEMBL4377324 | 0.75 | PYGL (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134175-A1 | INHIBITORS OF AKT ACTIVITY | Smithkline Beecham Corporation (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008121786-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-09 | — | — | WO | disclosed |