Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 8/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10927286 | 0.74 | — | — | |
| SCHEMBL14639314 | 0.74 | — | — | |
| SCHEMBL3823910 | 0.74 | — | — | |
| Hydrochloric Acid SCHEMBL30429172 | 0.72 | GPR84 (0.37) | POLBLMNAGPR84MEN1KMT2A | |
| SCHEMBL2483213 | 0.71 | PDE3B (0.42) | POLBLMNAGPR84MEN1KMT2A | |
| SCHEMBL4016016 | 0.71 | PDE3B (0.51) | GPR84MEN1KMT2ASMN1; SMN2TAAR1 | |
| SCHEMBL3855002 | 0.69 | HCAR2 (0.42) | POLBLMNAGPR84MEN1KMT2A | |
| SCHEMBL6294711 | 0.69 | GPR84 (0.38) | POLBGPR84MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1839150 | 0.69 | GPR84 (0.35) | POLBLMNAGPR84MEN1KMT2A | |
| SCHEMBL7419500 | 0.69 | GABRP (0.41) | POLBLMNAGPR84MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397351-B1 | PYRIMIDINE, TRIAZINE AND PYRAZINE DERIVATIVES AS GLUTAMATE RECEPTORS | HOFFMANN LA ROCHE (CH) | 2009-11-11 | — | — | EP | disclosed |
| CN-1146455-C | 1,2,4,5-tetrahydro-benzo[d] azepine compound | - | 2004-04-21 | — | — | CN | disclosed |
| CN-1283623-A | 1,2,4,5-tetrahydro-benzo[d] azepine compound | HAFMAN RAROCHE S A F (CH) | 2001-02-14 | — | — | CN | disclosed |