Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.36 |
| ▸ | HCAR1 | Q9BXC0 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4552842 | 0.80 | POLB (0.36) | HCAR2LMNAPOLBPDE3BPDE3A | |
| SCHEMBL803691 | 0.78 | GPR84 (0.41) | PKMLMNAPOLBPDE3BPDE3A | |
| SCHEMBL4552843 | 0.69 | POLB (0.37) | LMNAPOLBPDE3BPDE3AGPR84 | |
| SCHEMBL28746022 | 0.67 | CYP1A2 (0.46) | LMNAHCAR1ALDH1A1MEN1KMT2A | |
| SCHEMBL4552845 | 0.67 | POLB (0.38) | LMNAPOLBPDE3BPDE3ANPSR1 | |
| SCHEMBL713909 | 0.66 | POLB (0.55) | LMNAPOLBNPSR1GPR84NPC1 | |
| Thiouracil SCHEMBL2856254 | 0.65 | — | — | |
| SCHEMBL755723 | 0.65 | — | — | |
| SCHEMBL11359888 | 0.65 | — | — | |
| SCHEMBL83773 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009158258-A1 | HERBICIDAL DIHYDRO OXO SIX-MEMBERED AZINYL ISOXAZOLINES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2009-12-30 | — | — | WO | claimed |
| JP-5155863-A | — | — | None | — | — | JP | disclosed |
| CN-120077041-A | Tricyclic derivative compounds and use thereof | 韩美药品株式会社 | 2025-05-30 | — | — | CN | disclosed |
| EP-4543881-A1 | COMPOUNDS AND METHOD FOR PKMYT1 INHIBITION | Engine Biosciences Pte. Ltd. (SG) | 2025-04-30 | — | — | EP | disclosed |
| US-12264147-B2 | Substituted carboxamides as inhibitors of WDR5 protein-protein binding | Propellon Therapeutics Inc. (CA) | 2025-04-01 | — | — | US | disclosed |
| WO-2024080788-A1 | NOVEL TRICYCLIC DERIVATIVE COMPOUND AND USES THEREOF | 한미약품 주식회사 | 2024-04-18 | — | — | WO | disclosed |
| WO-2023249563-A1 | COMPOUNDS AND METHOD FOR PKMYT1 INHIBITION | ENGINE BIOSCIENCES PTE. LTD. (SG) | 2023-12-28 | — | — | WO | disclosed |
| EP-4273146-A1 | TRICYCLIC COMPOUND AND USE THEREOF | Nanjing Zaiming Pharmaceutical Co., Ltd. (CN) | 2023-11-08 | — | — | EP | disclosed |
| US-20230219926-A1 | SUBSTITUTED CARBOXAMIDES AS INHIBITORS OF WDR5 PROTEIN-PROTEIN BINDING | FACIT INC. (CA) | 2023-07-13 | — | — | US | disclosed |
| EP-3423451-B1 | INHIBITORS OF WDR5 PROTEIN-PROTEIN BINDING | PROPELLON THERAPEUTICS INC (CA) | 2022-08-17 | — | — | EP | disclosed |
| JP-2009126792-A | 5-SUBSTITUTED PHENYL-2-TRIFLUOROMETHYLPYRIMIDIN-6(1H)-ONE DERIVATIVE, METHOD FOR PRODUCING THE SAME AND HERBICIDE CONTAINING THE DERIVATIVE AS ACTIVE INGREDIENT | SAGAMI CHEM RES CENTER | 2009-06-11 | — | — | JP | disclosed |
| EP-0612317-A1 | SUBSTITUTED HETEROCYCLES AS ANGIOTENSIN II ANTAGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-08-31 | — | — | EP | disclosed |
| US-5256781-A | Anticholesterol, antilipemic, hypotensive agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-10-26 | — | — | US | disclosed |
| US-5236925-A | Hypotensive agents, treatment of congestive heart failure | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-08-17 | — | — | US | disclosed |
| WO-1993008170-A1 | SUBSTITUTED HETEROCYCLES AS ANGIOTENSIN II ANTAGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-04-29 | — | — | WO | disclosed |
| US-5187168-A | Hypotensive agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-02-16 | — | — | US | disclosed |
| EP-0396250-A1 | Pyrimidinone derivatives | ZENECA LIMITED (GB) | 1990-11-07 | — | — | EP | disclosed |
| EP-0357201-A2 | Pyridyl pyrimidinone derivatives with an insecticidal activity | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-03-07 | — | — | EP | disclosed |
| EP-0338686-A2 | Pyrimidinone derivatives | ZENECA LIMITED (GB) | 1989-10-25 | — | — | EP | disclosed |
| EP-0260621-A2 | 3-Aryl uracil-enol ethers and their use as herbicides | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1988-03-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12264147-B2 | Substituted carboxamides as inhibitors of WDR5 protein-protein binding | WDR5, WDR82, WDR1 | HCAR2 2443/4885KDM5A 142/4885KDM4C 957/4885 |
| US-20230219926-A1 | SUBSTITUTED CARBOXAMIDES AS INHIBITORS OF WDR5 PROTEIN-PROTEIN BINDING | WDR5, WDR82, WDR1 | HCAR2 2443/4885KDM5A 142/4885KDM4C 957/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.