Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 6/20 | 0.44 |
| ▸ | JAK2 | O60674 | 4/20 | 0.43 |
| ▸ | JAK1 | P23458 | 4/20 | 0.43 |
| ▸ | TYK2 | P29597 | 2/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20551867 | 0.84 | NOTUM (0.45) | BTKJAK2JAK1TYK2MGLL | |
| SCHEMBL26029500 | 0.84 | MGLL (0.39) | BTKJAK2JAK1TYK2MGLL | |
| SCHEMBL26976576 | 0.83 | MGLL (0.39) | BTKJAK2JAK1TYK2MGLL | |
| SCHEMBL7314599 | 0.80 | JAK1 (0.46) | JAK2JAK1 | |
| SCHEMBL24159061 | 0.79 | ROCK2 (0.45) | BTKJAK2JAK1TYK2ROCK2 | |
| SCHEMBL21816295 | 0.78 | TSHR (0.42) | — | |
| SCHEMBL19191027 | 0.76 | BTK (0.41) | BTKJAK2JAK1TYK2PDE4D | |
| SCHEMBL31226978 | 0.76 | BTK (0.41) | BTKJAK2JAK1TYK2PDE4D | |
| SCHEMBL175153 | 0.75 | BTK (0.52) | BTKJAK2JAK1TYK2 | |
| SCHEMBL27860905 | 0.75 | BTK (0.49) | BTKJAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010526-A1 | BENZIMIDAZOLE 5-SULFONAMIDE DERIVATIVES AS CANNABINOID 1 (CB1) RECEPTOR LIGANDS | AstraZeneca AB (SE) | 2009-01-07 | — | — | EP | claimed |
| WO-2007120101-A1 | BENZIMIDAZOLE 5-SULFONAMIDE DERIVATIVES AS CANNABINOID 1 (CB1) RECEPTOR LIGANDS | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | WO | claimed |