Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ABAT | P80404 | 1/20 | 0.37 |
| ▸ | QPCT | Q16769 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | BPTF | Q12830 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4553559 | 0.81 | QPCT (0.51) | NPSR1SMN1; SMN2ALDH1A1QPCTLMNA | |
| SCHEMBL11397317 | 0.79 | MAPT (0.41) | NPSR1SMN1; SMN2ALDH1A1HPGDALOX12 | |
| SCHEMBL21291833 | 0.76 | ATM (0.48) | ATMNPSR1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL4552953 | 0.73 | ABAT (0.44) | ATMSMN1; SMN2ALDH1A1KDM4ETDP1 | |
| SCHEMBL8789317 | 0.71 | SLC6A3 (0.50) | ALDH1A1RAB9AQPCTLMNA | |
| SCHEMBL4553183 | 0.70 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1GAAABATLMNA | |
| SCHEMBL11183414 | 0.70 | SMN1; SMN2 (0.41) | ATMNPSR1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL7947339 | 0.68 | TDP1 (0.36) | ALDH1A1TDP1POLB | |
| SCHEMBL11129662 | 0.67 | ATM (0.64) | ATMNPSR1ALDH1A1HPGDTDP1 | |
| SCHEMBL22972985 | 0.67 | ALDH1A1 (0.44) | NPSR1SMN1; SMN2ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090186834-A1 | DIPHENYLHETEROCYCLE CHOLESTEROL ABSORPTION INHIBITORS | MICROBIA, INC. (US) | 2009-07-23 | — | — | US | disclosed |
| WO-2008039829-A2 | DIPHENYLHETEROCYCLE CHOLESTEROL ABSORPTION INHIBITORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2008-04-03 | — | — | WO | disclosed |
| WO-2006102674-A2 | DIPHENYLHETEROCYCLE CHOLESTEROL ABSORPTION INHIBITORS | MICROBIA, INC. (US) | 2006-09-28 | — | — | WO | disclosed |
| US-5210210-A | CHIRAL AUXILIARIES AND THEIR USE IN THE SYNTHESIS OF CHIRAL MOLECULES | THE BRITISH PETROLEUM COMPANY P.L.C. (GB) | 1993-05-11 | — | — | US | disclosed |
| EP-0457469-A1 | Chiral auxiliaries and their use in the synthesis of chiral molecules | THE BRITISH PETROLEUM COMPANY P.L.C. (GB) | 1991-11-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090186834-A1 | DIPHENYLHETEROCYCLE CHOLESTEROL ABSORPTION INHIBITORS | NPC1L1, CYP46A1, NPC1 | ATM 4804/4885NPSR1 4168/4885SMN1; SMN2 3046/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.