Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TACR2 | P21452 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.33 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4553619 | 0.83 | LRRK2 (0.38) | L3MBTL1TACR2TACR1L3MBTL3 | |
| SCHEMBL4555362 | 0.74 | L3MBTL3 (0.43) | L3MBTL1L3MBTL3CYP2C9 | |
| SCHEMBL4554607 | 0.74 | L3MBTL3 (0.38) | L3MBTL1L3MBTL3 | |
| SCHEMBL18838584 | 0.71 | NR1H2 (0.40) | L3MBTL1TACR2TACR1L3MBTL3 | |
| SCHEMBL4555483 | 0.69 | L3MBTL3 (0.36) | L3MBTL1L3MBTL3 | |
| SCHEMBL4555067 | 0.68 | L3MBTL3 (0.38) | L3MBTL1L3MBTL3MMP13LMNA | |
| SCHEMBL18838603 | 0.68 | SLC6A4 (0.35) | TACR2TACR1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL3486479 | 0.67 | DCTPP1 (0.47) | MAPTL3MBTL1MAPK1ALDH1A1CYP1A2 | |
| SCHEMBL3486482 | 0.67 | DCTPP1 (0.47) | MAPTL3MBTL1MAPK1ALDH1A1CYP1A2 | |
| SCHEMBL18838604 | 0.66 | NR1H2 (0.41) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121661-A1 | BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | Merck & Co., Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008085316-A1 | BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO., INC. (US) | 2008-07-17 | — | — | WO | disclosed |