Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.38 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | CFB | P00751 | 3/20 | 0.34 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.33 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4554607 | 0.83 | L3MBTL3 (0.38) | L3MBTL3L3MBTL1ITGB3ITGA2B | |
| SCHEMBL4555067 | 0.81 | L3MBTL3 (0.38) | L3MBTL3L3MBTL1CFBSMYD3ITGB3 | |
| SCHEMBL4553619 | 0.79 | LRRK2 (0.38) | L3MBTL3L3MBTL1CCNCCDK8 | |
| SCHEMBL29213871 | 0.75 | ALDH1A1 (0.49) | — | |
| SCHEMBL26693343 | 0.74 | PARP14 (0.52) | PARP10PARP14HRH3CCNCCDK8 | |
| SCHEMBL26693337 | 0.74 | PARP14 (0.52) | PARP10PARP14HRH3CCNCCDK8 | |
| SCHEMBL4553277 | 0.74 | MAPT (0.35) | L3MBTL3L3MBTL1CYP2C9 | |
| SCHEMBL26693398 | 0.73 | PARP14 (0.57) | PARP10PARP14HRH3CFBCCNC | |
| SCHEMBL4433462 | 0.73 | PKM (0.34) | L3MBTL3L3MBTL1CYP2C9 | |
| SCHEMBL4555039 | 0.71 | GPR119 (0.48) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121661-A1 | BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | Merck & Co., Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008085316-A1 | BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO., INC. (US) | 2008-07-17 | — | — | WO | disclosed |