Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 7/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | TTK | P33981 | 2/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL220335 | 0.88 | CHEK1 (0.47) | CHEK1HRH3FGFR1PDGFRAFLT1 | |
| SCHEMBL16241883 | 0.84 | NOS1 (0.51) | CHEK1HRH3FGFR1TTKIGF1R | |
| SCHEMBL16241884 | 0.83 | CHEK1 (0.48) | CHEK1HRH3FGFR1TTKIGF1R | |
| SCHEMBL221859 | 0.75 | NOS1 (0.57) | CHEK1TTKIGF1RDYRK1BROCK2 | |
| SCHEMBL221344 | 0.72 | NOS1 (0.65) | CHEK1TTKIGF1RDYRK1B | |
| SCHEMBL5824113 | 0.72 | PDE7A (0.49) | CHEK1ROCK1 | |
| SCHEMBL221708 | 0.71 | NOS1 (0.45) | HRH3 | |
| SCHEMBL5140699 | 0.70 | NOS3 (0.53) | CHEK1TTKIGF1RDYRK1B | |
| SCHEMBL221586 | 0.70 | NMT1 (0.45) | CHEK1KCNH2ROCK1 | |
| SCHEMBL28813994 | 0.69 | CHEK1 (0.44) | CHEK1HRH3TTKIGF1RDYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009158646-A1 | THERAPEUTIC COMPUNDS AND RELATED METHODS OF USE | ELIXIR PHARMACEUTICALS, INC. (US) | 2009-12-30 | — | — | WO | disclosed |