Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4570113 | 0.88 | IRAK4 (0.33) | LMNAIRAK4ALDH1A1SMN1; SMN2 | |
| SCHEMBL962959 | 0.86 | HPGD (0.32) | LMNAIRAK4 | |
| SCHEMBL5120302 | 0.84 | IRAK4 (0.34) | LMNAIRAK4FGFR1FGFR4ALDH1A1 | |
| SCHEMBL962516 | 0.79 | IRAK4 (0.32) | IRAK4 | |
| SCHEMBL967553 | 0.79 | IRAK4 (0.33) | IRAK4 | |
| SCHEMBL963704 | 0.78 | PPARG (0.40) | IRAK4 | |
| SCHEMBL963357 | 0.78 | NR3C1 (0.33) | IRAK4 | |
| SCHEMBL966059 | 0.77 | IRAK4 (0.35) | IRAK4 | |
| SCHEMBL964636 | 0.77 | ALDH1A1 (0.35) | LMNAIRAK4ALDH1A1SMN1; SMN2 | |
| SCHEMBL966365 | 0.76 | IRAK4 (0.31) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118066-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | Takeda Pharmaceutical Company Limited (JP) | 2009-11-18 | — | — | EP | disclosed |
| WO-2009084614-A1 | IMIDAZOLE CARBONYL COMPOUND | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2009-07-09 | — | — | WO | disclosed |
| WO-2008099794-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-08-21 | — | — | WO | disclosed |