⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydroxyguanidine SCHEMBL116224 | 0.70 | — | — | |
| Pimagedine SCHEMBL7763659 | 0.70 | ALDH1A1 (0.43) | — | |
| SCHEMBL1169064 | 0.70 | — | — | |
| Biguanide SCHEMBL8039 | 0.70 | — | — | |
| Pimagedine SCHEMBL15307 | 0.70 | — | — | |
| Biguanide SCHEMBL18255803 | 0.70 | MAPK1 (0.31) | — | |
| Hydrochloric Acid SCHEMBL23478346 | 0.67 | — | — | |
| Pimagedine SCHEMBL1724778 | 0.67 | ALDH1A1 (0.40) | — | |
| Pimagedine SCHEMBL8446446 | 0.67 | — | — | |
| Pimagedine SCHEMBL19122 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 136 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115466251-B | Condensed heterocyclic compound, preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2024-06-21 | — | — | CN | claimed |
| CN-115504973-B | Benzisoxazole compound, preparation method, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2024-05-14 | — | — | CN | claimed |
| CN-115504973-A | Benzisoxazole compound, preparation method thereof, pharmaceutical composition and application | 中国医学科学院药物研究所 | 2022-12-23 | — | — | CN | claimed |
| EP-3466944-B1 | NICOTINYL ALCOHOL ETHER DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND USES THEREOF | INST MATERIA MEDICA CAMS (CN) | 2022-06-15 | — | — | EP | claimed |
| EP-3450423-B1 | BENZYL PHENYL ETHER DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND USES THEREOF | INST MATERIA MEDICA CAMS (CN) | 2022-06-15 | — | — | EP | claimed |
| CN-114591318-A | Pyrazolo heterocyclic compound, preparation method thereof, pharmaceutical composition and application | 中国医学科学院药物研究所 | 2022-06-07 | — | — | CN | claimed |
| CN-114507227-A | Benzisothiazole compound, preparation method thereof, pharmaceutical composition and application | 中国医学科学院药物研究所 | 2022-05-17 | — | — | CN | claimed |
| CN-114507243-A | Isothiazole heterocyclic compound, preparation method thereof, pharmaceutical composition and application thereof | 中国医学科学院药物研究所 | 2022-05-17 | — | — | CN | claimed |
| EP-3459926-B1 | PHENYLATE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND USES THEREOF | INST MATERIA MEDICA CAMS (CN) | 2021-11-24 | — | — | EP | claimed |
| US-10975049-B2 | Nicotinyl alcohol ether derivative, preparation method therefor, and pharmaceutical composition and uses thereof | INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2021-04-13 | — | — | US | claimed |
| WO-1996016031-A1 | AMINOGUANIDINE CARBOXYLATES FOR THE TREATMENT OF NON-INSULIN-DEPENDENT DIABETES MELLITUS | PHARMACIA & UPJOHN COMPANY (US) | 1996-05-30 | — | — | WO | claimed |
| US-5470847-A | Contraceptives by inhibiting ovulation | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1995-11-28 | — | — | US | claimed |
| WO-1995015753-A1 | OVULATION CONTROL BY REGULATING NITRIC OXIDE LEVELS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1995-06-15 | — | — | WO | claimed |
| EP-0592557-A4 | — | UNIV TEXAS (US) | 1994-08-03 | — | — | EP | claimed |
| EP-0597831-A1 | ARGININE ANTAGONISTS FOR INHIBITION OF SYSTEMIC HYPOTENSION ASSOCIATED WITH NITRIC OXIDE PRODUCTION OR ENDOTHELIAL DERIVED RELAXING FACTOR | THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1994-05-25 | — | — | EP | claimed |
| EP-0592557-A1 | NITRIC OXIDE SYNTHESIS INHIBITORS FOR POTENTIATING THE ACTION OF PRESSOR AGENTS IN CERTAIN HYPOTENSIVE PATIENTS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1994-04-20 | — | — | EP | claimed |
| US-5216025-A | Nitric oxide synthesis inhibitors for potentiating the action of pressor agents in certain hypotensive patients | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1993-06-01 | — | — | US | claimed |
| WO-1993000893-A1 | NITRIC OXIDE SYNTHESIS INHIBITORS FOR POTENTIATING THE ACTION OF PRESSOR AGENTS IN CERTAIN HYPOTENSIVE PATIENTS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1993-01-21 | — | — | WO | claimed |
| US-5028627-A | Controlling blood pressure during chemotherapy | CORNELL RESEARCH FOUNDATION, INC. (US) | 1991-07-02 | — | — | US | claimed |
| WO-1991004024-A1 | ARGININE ANTAGONISTS FOR INHIBITION OF SYSTEMIC HYPOTENSION ASSOCIATED WITH NITRIC OXIDE PRODUCTION OR ENDOTHELIAL DERIVED RELAXING FACTOR | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 1991-04-04 | — | — | WO | claimed |