Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 8/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 8/20 | 0.40 |
| ▸ | PTGFR | P43088 | 2/20 | 0.39 |
| ▸ | DHODH | Q02127 | 2/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 7/20 | 0.39 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.37 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.37 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4553637 | 0.84 | TBK1 (0.43) | TBK1GABRA1GABRB2TLR9TLR8 | |
| SCHEMBL4360503 | 0.77 | ADORA2A (0.56) | DHODHHSD17B10CSNK2A2CSNK2BADORA2A | |
| SCHEMBL24108914 | 0.70 | ADORA2A (0.42) | GABRA1GABRB2TLR9PTGFRDHODH | |
| SCHEMBL18089277 | 0.69 | PTGFR (0.66) | PTGFRDHODH | |
| SCHEMBL18075804 | 0.68 | DHODH (0.69) | PTGFRDHODH | |
| SCHEMBL5785541 | 0.67 | ADORA2A (0.52) | GABRA1GABRB2CYP1A2HSD17B10ADORA2A | |
| SCHEMBL24108930 | 0.66 | TLR9 (0.43) | TLR9TLR8PTGFRDHODHTLR7 | |
| Hydrochloric Acid SCHEMBL5787873 | 0.66 | ADORA2A (0.51) | GABRA1GABRB2CYP1A2HSD17B10ADORA2A | |
| SCHEMBL13646142 | 0.65 | ACMSD (0.50) | TBK1TLR9TLR8DHODHTLR7 | |
| SCHEMBL10887487 | 0.64 | GABRA1 (0.48) | GABRA1GABRB2CYP1A2HSD17B10ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090270450-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2009-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270450-A1 | CHEMICAL COMPOUNDS | CSF1R, CSF3R, FLT3 | TBK1 616/4885GABRA1 1123/4885GABRB2 1504/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.