Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | CMA1 | P23946 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP7 | P09237 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL65278 | 0.83 | CALM1 (0.42) | TAAR1CYP3A4ALDH1A1CALM1CMA1 | |
| SCHEMBL108087 | 0.72 | TAAR1 (0.77) | TAAR1CYP3A4ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL63220 | 0.71 | NR3C2 (0.47) | TAAR1ALDH1A1CYP1A2CMA1KDM4E | |
| SCHEMBL27720182 | 0.70 | ALDH1A1 (0.67) | TAAR1CYP3A4ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL1430901 | 0.70 | TRPM8 (0.65) | TAAR1CYP3A4ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL4429135 | 0.69 | CYP19A1 (0.44) | ALDH1A1CALM1KDM4EHDAC1MEN1 | |
| SCHEMBL64288 | 0.69 | TAAR1 (0.54) | TAAR1CYP3A4CYP1A2CALM1 | |
| SCHEMBL300007 | 0.68 | TAAR1 (0.62) | TAAR1CYP3A4ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL31318377 | 0.68 | CYP3A4 (0.59) | TAAR1CYP3A4ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL11874562 | 0.68 | CYP3A4 (0.57) | TAAR1CYP3A4ALDH1A1CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008075068-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |