Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | ALPI | P09923 | 1/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | XIAP | P98170 | 1/20 | 0.30 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL65279 | 0.86 | YAP1 (0.32) | SLC7A5 | |
| SCHEMBL64289 | 0.74 | CDC7 (0.32) | — | |
| SCHEMBL3563505 | 0.73 | MIF (0.43) | MIFPKMALPIPTGS1XIAP | |
| SCHEMBL1430902 | 0.72 | MIF (0.56) | MIFPKMKMT2AALPIPTGS1 | |
| SCHEMBL5073587 | 0.71 | MIF (0.39) | MIFPKMNPSR1KMT2AALPI | |
| SCHEMBL938718 | 0.71 | EPHX1 (0.37) | MIFPKMALDH1A1ALPIPTGS1 | |
| SCHEMBL3748652 | 0.71 | TRPA1 (0.40) | MIFPKMALPIPTGS1XIAP | |
| SCHEMBL15547346 | 0.70 | MTNR1A (0.43) | MIFPKMALDH1A1NPSR1KMT2A | |
| SCHEMBL5884516 | 0.70 | MTNR1A (0.41) | MIFPKMALDH1A1NPSR1KMT2A | |
| SCHEMBL2466830 | 0.70 | EPHX1 (0.55) | MIFPKMALDH1A1KMT2AALPI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008075068-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |