Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 3/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | AKT2 | P31751 | 1/20 | 0.35 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4431729 | 0.85 | CCR1 (0.40) | HDAC3HDAC1HDAC6KDM4EALDH1A1 | |
| SCHEMBL4553919 | 0.82 | AKT1 (0.38) | ANO1AKT1SCN9ASCN10AMEN1 | |
| SCHEMBL4380618 | 0.81 | ALDH1A1 (0.41) | ANO1PPARGAKT1AKT2AKT3 | |
| SCHEMBL4382045 | 0.79 | EPHX2 (0.37) | ANO1PPARGAKT1AKT2AKT3 | |
| SCHEMBL4379890 | 0.79 | AKT1 (0.43) | PPARGAKT1AKT2AKT3PPARA | |
| SCHEMBL4376050 | 0.78 | AKT1 (0.44) | HDAC3HDAC1HDAC2HDAC6ANO1 | |
| SCHEMBL3333499 | 0.78 | HDAC3 (0.39) | HDAC3HDAC1HDAC2HDAC6ANO1 | |
| SCHEMBL3333495 | 0.78 | HDAC3 (0.39) | HDAC3HDAC1HDAC2HDAC6ANO1 | |
| SCHEMBL13300019 | 0.75 | SCN9A (0.42) | HDAC3HDAC1HDAC2HDAC6AKT1 | |
| SCHEMBL4543991 | 0.74 | AKT1 (0.45) | AKT1AKT2AKT3EPHX2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134175-A1 | INHIBITORS OF AKT ACTIVITY | Smithkline Beecham Corporation (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008121786-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-09 | — | — | WO | disclosed |