Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL3 | Q96JM7 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL64298 | 0.82 | ALDH1A1 (0.43) | HDAC4HRH3ALDH1A1HPGDPOLB | |
| SCHEMBL81602 | 0.77 | HRH3 (0.46) | HRH3ALDH1A1HPGDNPC1POLB | |
| SCHEMBL5226095 | 0.74 | ALDH1A1 (0.46) | ALDH1A1HPGDPOLBKDM4E | |
| SCHEMBL6125963 | 0.73 | USP2 (0.51) | L3MBTL3L3MBTL1HDAC4HRH3NPC1 | |
| SCHEMBL5228374 | 0.73 | KMT2A (0.49) | L3MBTL1ALDH1A1HPGDNPC1POLB | |
| SCHEMBL6274318 | 0.72 | DAO (0.39) | ALDH1A1POLBKDM4E | |
| SCHEMBL4438126 | 0.70 | DAO (0.44) | L3MBTL1ALDH1A1NPC1POLBKDM4E | |
| SCHEMBL12663041 | 0.70 | HRH3 (0.44) | L3MBTL1HDAC4HRH3ALDH1A1KDM4E | |
| SCHEMBL28290140 | 0.69 | GAA (0.41) | L3MBTL3L3MBTL1ALDH1A1POLBACKR3 | |
| SCHEMBL4554523 | 0.69 | CHKA (0.41) | ALDH1A1NPC1POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008075068-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |