Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 2/20 | 0.36 |
| ▸ | CTSV | O60911 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 12/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16716189 | 0.86 | CTSL (0.37) | CTSLCTSVCTSBCTSSHDAC8 | |
| SCHEMBL1527186 | 0.84 | ROCK2 (0.40) | CTSLCTSVCTSBCTSSHDAC8 | |
| SCHEMBL4441518 | 0.83 | KMT2A (0.37) | KMT2AALDH1A1PPARD | |
| SCHEMBL1527253 | 0.82 | CTSL (0.35) | CTSLCTSVCTSBCTSSHDAC8 | |
| SCHEMBL12767734 | 0.81 | ATM (0.39) | CTSLCTSVCTSBCTSSKMT2A | |
| SCHEMBL4542245 | 0.79 | AKT1 (0.39) | CTSLCTSVCTSBCTSSHDAC8 | |
| SCHEMBL4384617 | 0.78 | HDAC8 (0.43) | CTSLCTSVCTSBCTSSHDAC8 | |
| SCHEMBL4540876 | 0.77 | AKT1 (0.43) | CTSLCTSVCTSBCTSSHDAC8 | |
| SCHEMBL4554107 | 0.76 | HDAC8 (0.45) | CTSLCTSVCTSBCTSSHDAC8 | |
| SCHEMBL4542689 | 0.74 | HDAC8 (0.39) | CTSLCTSVCTSBCTSSHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114388-A1 | INHIBITORS OF AKT ACTIVITY | Smithkline Beecham Corporation (US) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008098105-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-08-14 | — | — | WO | disclosed |