Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.39 |
| ▸ | CDK1 | P06493 | 2/20 | 0.39 |
| ▸ | PIM1 | P11309 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | FLT4 | P35916 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.39 |
| ▸ | GSK3A | P49840 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | PLK1 | P53350 | 2/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.39 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4808618 | 0.81 | CHEK2 (0.43) | CHEK2PARP1KDRPLECMAP4K4 | |
| SCHEMBL4147214 | 0.79 | PARP1 (0.40) | CHEK2PARP1CDK1CDK2CNR1 | |
| SCHEMBL30587300 | 0.72 | TRPA1 (0.57) | PARP1MAPK1CNR1PLEC | |
| SCHEMBL4846982 | 0.69 | CNR1 (0.45) | CHEK2PARP1CDK2FYNCNR1 | |
| SCHEMBL13808243 | 0.68 | CNR1 (0.57) | CNR1PLECKDM4ESMN1; SMN2 | |
| SCHEMBL4159476 | 0.67 | PARP1 (0.78) | HPGDSCHEK2PARP1FYNMAP4K4 | |
| SCHEMBL30958375 | 0.65 | CHEK2 (0.67) | HPGDSCHEK2PARP1FYNNQO2 | |
| SCHEMBL15547657 | 0.65 | CHEK2 (0.67) | HPGDSCHEK2PARP1FYNNQO2 | |
| SCHEMBL4145291 | 0.65 | POLB (0.44) | CNR1NPC1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL13808000 | 0.64 | CNR1 (0.61) | CNR1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009075691-A1 | CB-1 MODULATING COMPOUNDS AND THEIR USE | ACADIA PHARMACEUTICALS INC. (US) | 2009-06-18 | — | — | WO | disclosed |