Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.38 |
| ▸ | KIT | P10721 | 2/20 | 0.38 |
| ▸ | GAK | O14976 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | MARK1 | Q9P0L2 | 1/20 | 0.38 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4554153 | 0.69 | HPGDS (0.44) | CNR1CHEK2FYNCDK2PARP1 | |
| SCHEMBL30131529 | 0.66 | PTGS1 (0.54) | CHEK2MKNK2KITGAKPDGFRB | |
| SCHEMBL28203139 | 0.64 | PTGS1 (0.53) | CHEK2MKNK2KITGAKPDGFRB | |
| SCHEMBL1290758 | 0.64 | SIRT2 (0.36) | CHEK2CCNE2CCNE1CDK2MKNK2 | |
| SCHEMBL1926791 | 0.64 | PARP1 (0.63) | CHEK2FLT3PARP1 | |
| SCHEMBL18165201 | 0.63 | MAPK14 (0.52) | CHEK2MKNK2PTGS1PARP1GRM2 | |
| Hydrochloric Acid SCHEMBL18152459 | 0.63 | PTGS1 (0.48) | CHEK2MKNK2KITGAKPDGFRB | |
| SCHEMBL1132587 | 0.63 | TRPA1 (0.40) | — | |
| SCHEMBL12056910 | 0.62 | SIRT2 (0.50) | PARP1ABL1 | |
| SCHEMBL1927476 | 0.62 | BCL2L1 (0.64) | CHEK2MKNK2KITGAKPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937677-A1 | CB-1 MODULATING COMPOUNDS AND THEIR USE | Arcadia Pharmaceuticals Inc. (US) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007047737-A1 | CB-1 MODULATING COMPOUNDS AND THEIR USE | ACADIA PHARMACEUTICALS INC. (US) | 2007-04-26 | — | — | WO | disclosed |