Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ5 | P48544 | 2/20 | 0.41 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.41 |
| ▸ | CCNK | O75909 | 1/20 | 0.37 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.34 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3149134 | 0.94 | CA2 (0.40) | KCNJ5KCNJ3CCNKCDK12CA2 | |
| SCHEMBL20839815 | 0.94 | CA2 (0.40) | KCNJ5KCNJ3CCNKCDK12CA2 | |
| SCHEMBL3146503 | 0.75 | ALDH1A1 (0.44) | — | |
| SCHEMBL3146505 | 0.75 | ALDH1A1 (0.44) | — | |
| SCHEMBL25131168 | 0.75 | KCNJ5 (0.41) | KCNJ5KCNJ3CCNKCDK12CA2 | |
| SCHEMBL23773793 | 0.73 | CA2 (0.43) | KCNJ5KCNJ3CCNKCDK12CA2 | |
| SCHEMBL11156125 | 0.73 | CHRNB2 (0.43) | KCNJ5KCNJ3CCNKCDK12CA2 | |
| SCHEMBL11547597 | 0.72 | CA2 (0.42) | KCNJ5KCNJ3CCNKCDK12CA2 | |
| SCHEMBL17768160 | 0.71 | CA2 (0.41) | KCNJ5KCNJ3CCNKCDK12CA2 | |
| SCHEMBL17767927 | 0.71 | CA2 (0.41) | KCNJ5KCNJ3CCNKCDK12CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2136807-A1 | PYRROLO (3, 2, 1-IJ) QUINOLINE-4-ONE DERIVATIVES FOR TREATING TUBERCULOSIS | Glaxo Group Limited (GB) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008125594-A1 | PYRROLO (3, 2, 1-IJ) QUINOLINE-4-ONE DERIVATIVES FOR TREATING TUBERCULOSIS | GLAXO GROUP LIMITED (GB) | 2008-10-23 | — | — | WO | disclosed |