Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 4/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3140318 | 0.89 | GSTP1 (0.46) | PRMT5MMP2MMP13LMNACYP1A2 | |
| SCHEMBL3133827 | 0.86 | LMNA (0.51) | MMP2MMP13LMNACYP1A2PTGS1 | |
| SCHEMBL5382929 | 0.77 | GSTP1 (0.45) | PRMT5MMP2MMP13LMNACYP1A2 | |
| SCHEMBL5691564 | 0.75 | MMP13 (0.50) | MMP2MMP13LMNACYP1A2PTGS1 | |
| SCHEMBL16553890 | 0.74 | LMNA (0.56) | MMP2MMP13LMNACYP1A2PTGS1 | |
| SCHEMBL21874079 | 0.73 | LMNA (0.51) | MMP2MMP13LMNACYP1A2PTGS1 | |
| SCHEMBL10041856 | 0.73 | LMNA (0.54) | MMP2MMP13LMNACYP1A2PTGS1 | |
| SCHEMBL17072362 | 0.73 | LMNA (0.54) | MMP2MMP13LMNACYP1A2PTGS1 | |
| SCHEMBL3133794 | 0.72 | MMP2 (0.47) | MMP2MMP13LMNACYP1A2PTGS1 | |
| SCHEMBL4438507 | 0.71 | FFAR4 (0.38) | PRMT5MMP2MMP13LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137193-A2 | SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF | Sanofi-Aventis (FR) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008112483-A2 | SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF | SANOFI-AVENTIS (FR) | 2008-09-18 | — | — | WO | disclosed |