Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4553174 | 0.88 | HSD11B1 (0.39) | HSD11B1NR3C2EGLN1ALDH1A1MAPT | |
| SCHEMBL18729406 | 0.75 | EGLN1 (0.43) | HTR2ADRD2SLC6A2HTR2CSLC6A4 | |
| SCHEMBL23780230 | 0.73 | HTT (0.57) | HSD17B10OPRM1EGLN1MAPTHTT | |
| SCHEMBL25190199 | 0.71 | BCHE (0.38) | HTR2ANR3C2HRH1HSD17B10OPRM1 | |
| SCHEMBL4775639 | 0.71 | BCHE (0.45) | HSD17B10EGLN1HTTOPRL1 | |
| SCHEMBL3855958 | 0.70 | HRH4 (0.55) | DRD2MAPT | |
| SCHEMBL23780235 | 0.69 | EGLN1 (0.36) | NR3C2HRH1HSD17B10OPRM1EGLN1 | |
| SCHEMBL4554348 | 0.69 | HSD11B1 (0.57) | HSD11B1HTR2ANR3C2OPRM1CYP3A4 | |
| SCHEMBL7978258 | 0.68 | BCHE (0.50) | HTR2AHTR2CHRH1OPRM1EGLN1 | |
| SCHEMBL723687 | 0.68 | OPRM1 (0.53) | HTR2ADRD2SLC6A2HTR2CSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125726-A1 | SPIRO-PIPERIDINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008077811-A1 | SPIRO-PIPERIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-07-03 | — | — | WO | disclosed |