Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | BACE1 | P56817 | 2/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4554347 | 0.88 | HSD11B1 (0.42) | HSD11B1MAPTNR3C2EGLN1ALDH1A1 | |
| SCHEMBL5137269 | 0.73 | HTR3E (0.42) | LMNAMAPTTP53 | |
| SCHEMBL2213812 | 0.72 | HSD11B1 (0.53) | HSD11B1LMNAMAPTNR3C2TP53 | |
| SCHEMBL3840904 | 0.70 | MAPT (0.44) | LMNAMAPTKCNK2TP53BACE1 | |
| SCHEMBL5136557 | 0.67 | AVPR1A (0.44) | — | |
| SCHEMBL7678237 | 0.64 | PDK2 (0.46) | BACE1TDP1L3MBTL1 | |
| SCHEMBL18729406 | 0.64 | EGLN1 (0.43) | BACE1EGLN1 | |
| SCHEMBL29098518 | 0.64 | CASP1 (0.39) | BACE1ALDH1A1GABRA1GABRB2 | |
| SCHEMBL31258947 | 0.63 | ALDH1A1 (0.45) | LMNAMAPTKCNK2BACE1ALDH1A1 | |
| SCHEMBL22471605 | 0.63 | OPRK1 (0.41) | LMNAMAPTTP53BACE1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125726-A1 | SPIRO-PIPERIDINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008077811-A1 | SPIRO-PIPERIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-07-03 | — | — | WO | disclosed |