Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19398221 | 0.84 | TSHR (0.44) | TSHRNPSR1ADRB2KDM1AMAPKAPK2 | |
| SCHEMBL11028997 | 0.78 | TSHR (0.45) | TSHRNPSR1ADRB2KDM1AMAPKAPK2 | |
| SCHEMBL7121558 | 0.73 | MAPKAPK2 (0.51) | MAPKAPK2 | |
| SCHEMBL19607654 | 0.73 | TSHR (0.44) | TSHRNPSR1GLASLC18A2 | |
| SCHEMBL19607652 | 0.73 | TSHR (0.44) | TSHRNPSR1GLASLC18A2 | |
| SCHEMBL7436594 | 0.73 | GLA (0.44) | TSHRMAPKAPK2GLA | |
| SCHEMBL19225930 | 0.73 | TSHR (0.44) | TSHRNPSR1MAPKAPK2GLA | |
| SCHEMBL15654433 | 0.72 | ALDH1A1 (0.47) | TSHRNPSR1SLC18A2 | |
| SCHEMBL6967406 | 0.71 | TSHR (0.42) | TSHRNPSR1ADRB2KDM1AMAPKAPK2 | |
| SCHEMBL7221778 | 0.71 | FABP7 (0.45) | TSHRMAPKAPK2GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2073811-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES | Deciphera Pharmaceuticals, LLC. (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008046003-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF MYLEOPROLIFERATIVE DISEASES AND OTHER PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-04-17 | — | — | WO | disclosed |