Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 2/20 | 0.49 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.44 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3486845 | 0.83 | GPR119 (0.69) | GPR119LMNAKDM4EHTTSMN1; SMN2 | |
| SCHEMBL13505609 | 0.81 | CNR1 (0.47) | GPR119CNR1CNR2ITGB3ITGA2B | |
| SCHEMBL18641154 | 0.81 | DRD2 (0.52) | CHRNA10CHRNA9DRD2DRD4DRD3 | |
| SCHEMBL13506522 | 0.80 | USP2 (0.64) | CASRHPGDSGPR119LMNAUSP2 | |
| SCHEMBL19835711 | 0.80 | HDAC6 (0.63) | CHRNA10CHRNA9LMNAHDAC3HDAC8 | |
| SCHEMBL4768603 | 0.79 | TMEM97 (0.57) | LMNASMN1; SMN2 | |
| SCHEMBL3485750 | 0.77 | GPR119 (0.47) | GPR119USP2SMN1; SMN2 | |
| SCHEMBL4555361 | 0.77 | GPR119 (0.66) | CHRNA10CHRNA9GPR119LMNAUSP2 | |
| SCHEMBL19835907 | 0.77 | GAA (0.60) | CHRNA10CHRNA9LMNAHDAC3HDAC8 | |
| SCHEMBL8506701 | 0.76 | ITGB3 (0.52) | CHRNA10CHRNA9HPGDSITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121661-A1 | BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | Merck & Co., Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008085316-A1 | BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO., INC. (US) | 2008-07-17 | — | — | WO | disclosed |