Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.37 |
| ▸ | PI4KA | P42356 | 1/20 | 0.36 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.36 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 9/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | OGG1 | O15527 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3593099 | 0.74 | CSNK1D (0.44) | HRH4CSNK1DCSNK1E | |
| SCHEMBL2773822 | 0.66 | HTT (0.53) | SIGMAR1 | |
| SCHEMBL2773819 | 0.66 | HTT (0.53) | SIGMAR1 | |
| SCHEMBL19035631 | 0.64 | DRD2 (0.52) | HRH4HRH3 | |
| SCHEMBL12663092 | 0.62 | MBTD1 (0.61) | HDAC4HRH3 | |
| SCHEMBL17127953 | 0.62 | MBTD1 (0.61) | HDAC4HRH3 | |
| SCHEMBL18427064 | 0.61 | BPTF (0.46) | HRH3 | |
| SCHEMBL27382018 | 0.61 | HDAC4 (0.47) | HRH4KMT2AHDAC4HRH3 | |
| SCHEMBL38651777 | 0.61 | HDAC4 (0.47) | HRH4KMT2AHDAC4HRH3 | |
| SCHEMBL16570211 | 0.60 | HRH3 (0.49) | HRH4HDAC4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124954-A2 | PURINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS FOR THE TREATMENT OF PLASMODIUM RELATED DISEASES | IRM LLC (BM) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008094737-A2 | PURINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS FOR THE TREATMENT OF PLASMODIUM RELATED DISEASES | IRM LLC (BM) | 2008-08-07 | — | — | WO | disclosed |