Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 13/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3487514 | 0.87 | GPR119 (0.61) | GPR119 | |
| SCHEMBL4555482 | 0.74 | GPR119 (0.46) | CHRM4GPR119LOXL2CHRM2CHRM5 | |
| SCHEMBL14138631 | 0.74 | GPR119 (0.49) | CHRM4GPR119LOXL2 | |
| SCHEMBL3108697 | 0.74 | HRH4 (0.46) | HRH4GRM5 | |
| SCHEMBL4129398 | 0.73 | KCNH2 (0.45) | GPR119LOXL2GRM5 | |
| SCHEMBL4555152 | 0.72 | GPR119 (0.70) | CHRM4GPR119LOXL2 | |
| SCHEMBL4555141 | 0.72 | GPR119 (0.47) | CHRM4GPR119LOXL2 | |
| SCHEMBL624559 | 0.70 | GRM5 (0.59) | GRM5 | |
| SCHEMBL622223 | 0.70 | HDAC1 (0.46) | GRM5 | |
| SCHEMBL4555360 | 0.70 | SPHK2 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121661-A1 | BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | Merck & Co., Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008085316-A1 | BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO., INC. (US) | 2008-07-17 | — | — | WO | disclosed |