Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.47 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3487611 | 0.83 | GPR119 (0.69) | GPR119 | |
| SCHEMBL14138631 | 0.83 | GPR119 (0.49) | GPR119KMOLOXL2CHRM4 | |
| SCHEMBL4555482 | 0.80 | GPR119 (0.46) | GPR119KMOLOXL2CHRM4 | |
| SCHEMBL4555152 | 0.77 | GPR119 (0.70) | GPR119KMOLOXL2CHRM4 | |
| SCHEMBL4555359 | 0.72 | CHRM4 (0.46) | GPR119LOXL2CHRM4 | |
| SCHEMBL4554650 | 0.71 | GPR119 (0.52) | GPR119 | |
| SCHEMBL20445971 | 0.69 | KMO (0.44) | KMOLOXL2 | |
| SCHEMBL20165804 | 0.69 | RIPK1 (0.68) | — | |
| SCHEMBL20165803 | 0.69 | RIPK1 (0.68) | — | |
| SCHEMBL3486611 | 0.69 | GPR119 (0.68) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121661-A1 | BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | Merck & Co., Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008085316-A1 | BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO., INC. (US) | 2008-07-17 | — | — | WO | disclosed |