Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHAT | P28329 | 5/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.52 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.48 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.48 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1425978 | 0.95 | — | — | |
| Hydrochloric Acid SCHEMBL11149900 | 0.92 | HDAC8 (0.54) | CHATALDH1A1CYP2A6HDAC8ACHE | |
| Iodide SCHEMBL7049251 | 0.92 | HDAC8 (0.54) | CHATALDH1A1CYP2A6HDAC8ACHE | |
| Formic Acid SCHEMBL31029236 | 0.88 | HDAC8 (0.50) | CHATALDH1A1CYP2A6HDAC8ACHE | |
| SCHEMBL300426 | 0.86 | CHAT (0.61) | CHATALDH1A1CYP2A6HDAC8ACHE | |
| SCHEMBL4625849 | 0.86 | CHAT (0.61) | CHATALDH1A1CYP2A6HDAC8ACHE | |
| SCHEMBL1323372 | 0.82 | CHAT (0.47) | CHATALDH1A1CYP2A6HDAC8SLC22A2 | |
| Water SCHEMBL25192063 | 0.80 | CHAT (0.46) | CHATALDH1A1CYP2A6HDAC8SLC22A2 | |
| Sulfuric Acid SCHEMBL7788002 | 0.78 | CHAT (0.52) | CHATALDH1A1CYP2A6HDAC8ACHE | |
| Sulfuric Acid SCHEMBL7787999 | 0.78 | CHAT (0.52) | CHATALDH1A1CYP2A6HDAC8RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125684-A2 | COLCHICINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND USE IN THE MEDICAL FIELD | Fringuelli, Francesco (IT) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008102397-A2 | COLCHICINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND USE IN THE MEDICAL FIELD | FRINGUELLI FRANCESCO (IT) | 2008-08-28 | — | — | WO | disclosed |