Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | RECQL | P46063 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15010487 | 0.98 | USP2 (0.63) | USP2L3MBTL1TSHRMAPK1RECQL | |
| SCHEMBL7861726 | 0.88 | L3MBTL1 (0.63) | USP2L3MBTL1TSHRMAPK1RECQL | |
| SCHEMBL12189227 | 0.86 | USP2 (0.71) | USP2L3MBTL1TSHRMAPK1RECQL | |
| SCHEMBL12646347 | 0.84 | USP2 (0.68) | USP2L3MBTL1TSHRMAPK1RECQL | |
| SCHEMBL13176134 | 0.84 | LMNA (0.68) | USP2L3MBTL1TSHRGAAMEN1 | |
| SCHEMBL17069869 | 0.84 | USP2 (0.62) | USP2L3MBTL1TSHRGAANPSR1 | |
| SCHEMBL7077124 | 0.84 | MAPT (0.59) | USP2GAALMNAMAPTSMN1; SMN2 | |
| SCHEMBL27532497 | 0.83 | USP2 (0.67) | USP2GAANPSR1MEN1KMT2A | |
| SCHEMBL10312340 | 0.83 | USP2 (0.61) | USP2L3MBTL1TSHRMAPK1RECQL | |
| SCHEMBL27538663 | 0.81 | GPR183 (0.53) | USP2L3MBTL1GAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134714-A1 | TRICYCLIC ISOQUINOLINE DERIVATIVES FOR TREATMENT OF OBESITY | Biovitrum AB (publ) (SE) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008110598-A1 | TRICYCLIC ISOQUINOLINE DERIVATIVES FOR TREATMENT OF OBESITY | BIOVITRUM AB (PUBL) (SE) | 2008-09-18 | — | — | WO | disclosed |