Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 3/20 | 0.46 |
| ▸ | CA2 | P00918 | 3/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA7 | P43166 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.46 |
| ▸ | XDH | P47989 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4672838 | 0.77 | CA1 (0.57) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL4433135 | 0.76 | VCAM1 (0.53) | ALDH1A1HPGDTSHRMEN1KMT2A | |
| SCHEMBL4446049 | 0.76 | VCAM1 (0.53) | ALDH1A1HPGDTSHRMEN1KMT2A | |
| SCHEMBL15441153 | 0.72 | TSHR (0.57) | KDM4EALDH1A1MAPTGAACA1 | |
| SCHEMBL13220716 | 0.70 | CA1 (0.53) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL7582479 | 0.69 | CA1 (0.52) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL18892782 | 0.68 | CA1 (0.50) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL10368169 | 0.68 | CA12 (0.65) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL16159970 | 0.68 | CA1 (0.50) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL28377004 | 0.68 | KDM4E (0.59) | KDM4EALDH1A1MAPTHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121656-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | Pfizer Products Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008084300-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER PRODUCTS INC. (US) | 2008-07-17 | — | — | WO | disclosed |