Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 10/20 | 0.59 |
| ▸ | NOS3 | P29474 | 3/20 | 0.55 |
| ▸ | NOS1 | P29475 | 3/20 | 0.55 |
| ▸ | NOS2 | P35228 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15689737 | 0.84 | NOS3 (0.60) | NCF1NOS3NOS1NOS2KDM4E | |
| SCHEMBL7499287 | 0.83 | NOS3 (0.64) | NOS3NOS1NOS2KDM4EMEN1 | |
| SCHEMBL31348007 | 0.83 | NOS3 (0.64) | NOS3NOS1NOS2KDM4EMEN1 | |
| SCHEMBL29615484 | 0.82 | NOS3 (0.63) | NCF1NOS3NOS1NOS2KDM4E | |
| SCHEMBL25595272 | 0.82 | NOS3 (0.58) | NOS3NOS1NOS2KDM4EMEN1 | |
| SCHEMBL731492 | 0.82 | NOS3 (0.63) | NCF1NOS3NOS1NOS2KDM4E | |
| SCHEMBL11612193 | 0.79 | TSHR (0.58) | NOS3NOS1NOS2 | |
| SCHEMBL21999454 | 0.78 | NOS3 (0.57) | NOS3NOS1NOS2KDM4EMEN1 | |
| SCHEMBL26462412 | 0.77 | NCF1 (0.46) | NCF1NOS3NOS1NOS2KDM4E | |
| SCHEMBL19950985 | 0.77 | NOS3 (0.55) | NCF1NOS3NOS1NOS2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137184-A1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS RECEPTOR TYROSINE KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008124323-A1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS RECEPTOR TYROSINE KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2008-10-16 | — | — | WO | disclosed |