Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21464610 | 0.85 | USP2 (0.48) | USP2PKMKMT2AMAPTALDH1A1 | |
| SCHEMBL26144787 | 0.84 | USP2 (0.47) | USP2PKMKMT2AMAPTALDH1A1 | |
| SCHEMBL11178574 | 0.84 | MAPT (0.60) | USP2KMT2AMAPTLMNAHTT | |
| SCHEMBL28308929 | 0.82 | ALDH1A1 (0.67) | USP2PKMKMT2AMAPTALDH1A1 | |
| SCHEMBL31684030 | 0.82 | ALDH1A1 (0.67) | USP2PKMKMT2AMAPTALDH1A1 | |
| SCHEMBL4555427 | 0.82 | ALDH1A1 (0.67) | USP2PKMKMT2AMAPTALDH1A1 | |
| SCHEMBL7096080 | 0.80 | USP2 (0.80) | USP2PKMKMT2AMAPTALDH1A1 | |
| SCHEMBL4554939 | 0.80 | USP2 (0.80) | USP2PKMKMT2AMAPTALDH1A1 | |
| SCHEMBL14489550 | 0.79 | ALDH1A1 (0.69) | PKMKMT2AMAPTALDH1A1LMNA | |
| SCHEMBL8217672 | 0.79 | PKM (0.53) | USP2PKMKMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134714-A1 | TRICYCLIC ISOQUINOLINE DERIVATIVES FOR TREATMENT OF OBESITY | Biovitrum AB (publ) (SE) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008110598-A1 | TRICYCLIC ISOQUINOLINE DERIVATIVES FOR TREATMENT OF OBESITY | BIOVITRUM AB (PUBL) (SE) | 2008-09-18 | — | — | WO | disclosed |