Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 4/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA6 | P23280 | 1/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | LPL | P06858 | 1/20 | 0.31 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7452989 | 0.74 | ENPP2 (0.39) | ENPP2CA4CA6CA5ACA7 | |
| SCHEMBL154802 | 0.72 | CA2 (0.42) | ENPP2CA4CA6CA5ACA7 | |
| SCHEMBL21469007 | 0.72 | HDAC8 (0.36) | ENPP2CA4CA6CA5ACA7 | |
| SCHEMBL9523 | 0.72 | HDAC1 (0.38) | ENPP2CA4CA6CA5ACA7 | |
| SCHEMBL16361627 | 0.72 | ENPP2 (0.33) | ENPP2CA4CA6CA5ACA7 | |
| SCHEMBL1427905 | 0.72 | ENPP2 (0.42) | ENPP2CA4CA6CA5ACA7 | |
| Hydrochloric Acid SCHEMBL29955269 | 0.70 | HDAC1 (0.37) | ENPP2CA4CA6CA5ACA7 | |
| SCHEMBL15120297 | 0.69 | KDM4E (0.44) | ENPP2CA4CA6CA5ACA7 | |
| SCHEMBL2235592 | 0.69 | CA4 (0.31) | ENPP2CA4CA6CA5ACA7 | |
| SCHEMBL14552625 | 0.69 | ENPP2 (0.35) | ENPP2CA4CA6CA5ACA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114949-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008070740-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2008-06-12 | — | — | WO | disclosed |