Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | SSTR4 | P31391 | 4/20 | 0.37 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | HRH2 | P25021 | 4/20 | 0.36 |
| ▸ | HRH1 | P35367 | 4/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3354937 | 0.83 | CTSK (0.36) | CTSKKCNA3CA1CA2SSTR4 | |
| SCHEMBL3352854 | 0.83 | CTSK (0.36) | CTSKKCNA3CA1CA2SSTR4 | |
| SCHEMBL3357087 | 0.83 | CTSK (0.36) | CTSKKCNA3CA1CA2SSTR4 | |
| SCHEMBL13387530 | 0.83 | CTSK (0.36) | CTSKKCNA3CA1CA2SSTR4 | |
| SCHEMBL28826192 | 0.82 | SSTR4 (0.47) | CTSKCA1CA2SSTR4SSTR1 | |
| SCHEMBL18530346 | 0.81 | CTSK (0.57) | CTSKKCNA3CA1CA2DRD2 | |
| SCHEMBL13583572 | 0.81 | CTSK (0.57) | CTSKKCNA3CA1CA2DRD2 | |
| SCHEMBL13583571 | 0.81 | CTSK (0.57) | CTSKKCNA3CA1CA2DRD2 | |
| SCHEMBL3355159 | 0.79 | GSK3B (0.35) | SSTR4SSTR1 | |
| SCHEMBL17185074 | 0.79 | KMT2A (0.53) | KCNA3SSTR4SSTR1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101611038-B | 2-quinolinone and 2-quinoxalinone-derivatives and their use as antibacterial agents | ASTRAZENECA AB | 2012-06-13 | — | — | CN | disclosed |
| CN-101611038-A | 2-quinolinone and 2-quinoxalinone-derivatives and their use as antibacterial agents | ASTRAZENECA AB (SE) | 2009-12-23 | — | — | CN | disclosed |
| EP-2121702-A1 | 2-QUINOLINONE AND 2-QUINOXALINONE- DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | AstraZeneca AB (SE) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008071961-A1 | 2-QUINOLINONE AND 2-QUINOXALINONE- DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2008-06-19 | — | — | WO | disclosed |