Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 3/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 9/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4161565 | 0.76 | SLC6A9 (0.61) | OPRM1SLC6A9CHRM1 | |
| Hydrochloric Acid SCHEMBL4149476 | 0.74 | SLC6A9 (0.60) | SLC6A9MEN1KMT2ACHRM1 | |
| SCHEMBL4148214 | 0.72 | CYP1A2 (0.53) | OPRD1OPRM1OPRK1 | |
| SCHEMBL29968471 | 0.72 | CYP1A2 (0.53) | OPRD1OPRM1OPRK1 | |
| SCHEMBL4148207 | 0.72 | CYP1A2 (0.53) | OPRD1OPRM1OPRK1 | |
| SCHEMBL6476373 | 0.69 | HTT (0.42) | OPRD1MEN1KMT2A | |
| SCHEMBL6652382 | 0.69 | SLC6A9 (0.60) | OPRD1OPRM1OPRK1SLC6A9 | |
| SCHEMBL4135352 | 0.69 | SLC6A9 (0.81) | OPRD1OPRM1OPRK1OPRL1SLC6A9 | |
| SCHEMBL4135348 | 0.69 | SLC6A9 (0.81) | OPRD1OPRM1OPRK1OPRL1SLC6A9 | |
| SCHEMBL4135358 | 0.69 | SLC6A9 (0.81) | OPRD1OPRM1OPRK1OPRL1SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041088-A1 | GLYCINE TRANSPORTER-1 INHIBITORS | Amgen Inc. (US) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008002583-A1 | GLYCINE TRANSPORTER-1 INHIBITORS | AMGEN INC. (US) | 2008-01-03 | — | — | WO | disclosed |