SCHEMBL4148207

SCHEMBL4148207

C[C@@H]1CN([C@H](c2ccc(C#N)cc2)c2cccc(O)c2)[C@@H](C)CN1CC(=O)O

nearest known ligand 0.62

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.53
CYP3A4 P08684 1/20 0.53
CYP2C9 P11712 1/20 0.53
HPGD P15428 1/20 0.53
OPRM1 P35372 1/20 0.53
OPRD1 P41143 1/20 0.53
OPRK1 P41145 1/20 0.53
SIGMAR1 Q99720 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29968471 1.00 CYP1A2 (0.53) CYP1A2CYP3A4CYP2C9HPGDOPRM1
SCHEMBL4148214 1.00 CYP1A2 (0.53) CYP1A2CYP3A4CYP2C9HPGDOPRM1
SCHEMBL6937064 0.90 CYP1A2 (0.57) CYP1A2CYP3A4CYP2C9HPGDOPRM1
SCHEMBL6937062 0.90 CYP1A2 (0.57) CYP1A2CYP3A4CYP2C9HPGDOPRM1
SCHEMBL6925777 0.85 CYP1A2 (0.49) CYP1A2CYP3A4CYP2C9HPGDOPRM1
SCHEMBL6926737 0.84 OPRD1 (0.67) CYP1A2CYP3A4CYP2C9HPGDOPRM1
SCHEMBL6935130 0.84 OPRD1 (0.67) CYP1A2CYP3A4CYP2C9HPGDOPRM1
SCHEMBL6935555 0.84 OPRD1 (0.67) CYP1A2CYP3A4CYP2C9HPGDOPRM1
SCHEMBL6925678 0.83 CYP1A2 (0.47) CYP1A2CYP3A4CYP2C9HPGDOPRM1
SCHEMBL4157535 0.81 SLC6A9 (0.67) CYP1A2CYP3A4CYP2C9HPGDOPRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080004289-A1 Glycine transporter-1 inhibitors AMGEN INC. 2008-01-03 US claimed
US-20250302823-A1 COMPOSITIONS AND METHODS FOR TREATING HEPATIC PORPHYRIAS WITH GLYCINE TRANSPORT INHIBITORS DISC MEDICINE, INC. 2025-10-02 US disclosed
US-20250248995-A1 COMPOSITIONS AND METHODS FOR TREATING POLYCYTHEMIA DISC MEDICINE, INC. 2025-08-07 US disclosed
US-20240325382-A1 COMPOSITIONS AND METHODS FOR TREATING ANEMIA ASSOCIATED WITH A RIBOSOMAL DISORDER DISC MEDICINE, INC. 2024-10-03 US disclosed
US-20240269132-A1 COMPOSITIONS AND METHODS FOR TREATING POLYCYTHEMIA DISC MEDICINE INC (US) 2024-08-15 US disclosed
US-11813257-B2 Methods of treating erythropoietic protoporphyria, X-linked protoporphyria, or congenital erythropoietic porphyria with glycine transport inhibitors DISC MEDICINE, INC. (US) 2023-11-14 US disclosed
US-20210283129-A1 METHODS OF TREATING ERYTHROPOIETIC PROTOPORPHYRIA, X-LINKED PROTOPORPHYRIA, OR CONGENITAL ERYTHROPOIETIC PORPHYRIA WITH GLYCINE TRANSPORT INHIBITORS DISC MEDICINE, INC. 2021-09-16 US disclosed
US-9663476-B2 Glycine transporter-1 inhibitors AMGEN INC. (US) 2017-05-30 US disclosed
EP-2947067-A1 Glycine transporter-1 inhibitors Amgen, Inc (US) 2015-11-25 EP disclosed
US-20150307457-A1 GLYCINE TRANSPORTER-1 INHIBITORS AMGEN INC. (US) 2015-10-29 US disclosed
EP-2041088-B1 GLYCINE TRANSPORTER-1 INHIBITORS AMGEN INC (US) 2014-01-08 EP disclosed
EP-2565183-A1 Glycine transporter-1 inhibitors Amgen Inc. (US) 2013-03-06 EP disclosed
US-8183244-B2 Glycine transporter-1 inhibitors AMGEN INC. (US) 2012-05-22 US disclosed
US-20090227595-A1 GLYCINE TRANSPORTER-1 INHIBITORS HITCHCOCK STEPHEN 2009-09-10 US disclosed
US-7538114-B2 Glycine transporter-1 inhibitors AMGEN INC. (US) 2009-05-26 US disclosed
US-20080004289-A1 Glycine transporter-1 inhibitors AMGEN INC. 2008-01-03 US disclosed
EP-0983251-B1 ANTI-INFLAMMATORY PIPERAZINYL-BENZYL-TETRAZOLE DERIVATIVES AND INTERMEDIATES THEREOF PFIZER LTD (GB) 2004-06-23 EP disclosed
US-6514975-B1 Tetrazoles as selective agonists for the delta opioid receptor PFIZER INC 2003-02-04 US disclosed
EP-0983251-A1 ANTI-INFLAMMATORY PIPERAZINYL-BENZYL-TETRAZOLE DERIVATIVES AND INTERMEDIATES THEREOF Pfizer Limited (GB) 2000-03-08 EP disclosed
WO-1998052929-A1 ANTI-INFLAMMATORY PIPERAZINYL-BENZYL-TETRAZOLE DERIVATIVES AND INTERMEDIATES THEREOF PFIZER LIMITED (GB) 1998-11-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240325382-A1 COMPOSITIONS AND METHODS FOR TREATING ANEMIA ASSOCIATED WITH A RIBOSOMAL DISORDER TRMT1, AARS1, GFPT1 CYP1A2 2356/4885CYP3A4 2122/4885CYP2C9 2392/4885
US-20090227595-A1 GLYCINE TRANSPORTER-1 INHIBITORS SLC18A2, SLC7A11, SLC6A5 CYP1A2 993/4885CYP3A4 1018/4885CYP2C9 1128/4885
US-20250302823-A1 COMPOSITIONS AND METHODS FOR TREATING HEPATIC PORPHYRIAS WITH GLYCINE TRANSPORT INHIBITORS SLC10A1, GFPT1, GLS2 CYP1A2 484/4885CYP3A4 341/4885CYP2C9 347/4885
US-20240269132-A1 COMPOSITIONS AND METHODS FOR TREATING POLYCYTHEMIA SLC16A1, SLC7A1, SLC6A9 CYP1A2 1469/4885CYP3A4 1001/4885CYP2C9 719/4885
US-20250248995-A1 COMPOSITIONS AND METHODS FOR TREATING POLYCYTHEMIA SLC16A1, SLC7A1, SLC6A9 CYP1A2 1469/4885CYP3A4 1001/4885CYP2C9 719/4885
US-20210283129-A1 METHODS OF TREATING ERYTHROPOIETIC PROTOPORPHYRIA, X-LINKED PROTOPORPHYRIA, OR CONGENITAL ERYTHROPOIETIC PORPHYRIA WITH GLYCINE TRANSPORT INHIBITORS GFPT1, MPST, XPNPEP1 CYP1A2 1036/4885CYP3A4 946/4885CYP2C9 917/4885
US-20080004289-A1 Glycine transporter-1 inhibitors SLC18A2, SLC7A11, SLC6A5 CYP1A2 993/4885CYP3A4 1018/4885CYP2C9 1128/4885
US-20150307457-A1 GLYCINE TRANSPORTER-1 INHIBITORS SLC18A2, SLC7A11, SLC6A5 CYP1A2 993/4885CYP3A4 1018/4885CYP2C9 1128/4885
US-11813257-B2 Methods of treating erythropoietic protoporphyria, X-linked protoporphyria, or congenital erythropoietic porphyria with glycine transport inhibitors GFPT1, MPST, XPNPEP1 CYP1A2 1036/4885CYP3A4 946/4885CYP2C9 917/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.