SCHEMBL6652382

SCHEMBL6652382

C[C@H](C(=O)O)N1CCN([C@H](c2ccc(C#N)cc2)c2cccc(O)c2)[C@@H](C)C1

nearest known ligand 0.60

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
SLC6A9 P48067 7/20 0.60
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2C9 P11712 1/20 0.40
HPGD P15428 1/20 0.40
OPRM1 P35372 1/20 0.40
OPRD1 P41143 1/20 0.40
OPRK1 P41145 1/20 0.40
SIGMAR1 Q99720 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6925678 0.78 CYP1A2 (0.47) CYP1A2CYP3A4CYP2C9HPGDOPRM1
SCHEMBL29968471 0.78 CYP1A2 (0.53) CYP1A2CYP3A4CYP2C9HPGDOPRM1
SCHEMBL4148207 0.78 CYP1A2 (0.53) CYP1A2CYP3A4CYP2C9HPGDOPRM1
SCHEMBL4148214 0.78 CYP1A2 (0.53) CYP1A2CYP3A4CYP2C9HPGDOPRM1
SCHEMBL4144880 0.76 SLC6A9 (1.00) SLC6A9
SCHEMBL4144885 0.76 SLC6A9 (1.00) SLC6A9
SCHEMBL6924358 0.74 OPRD1 (0.40) CYP1A2CYP3A4CYP2C9HPGDOPRM1
SCHEMBL6925777 0.73 CYP1A2 (0.49) CYP1A2CYP3A4CYP2C9HPGDOPRM1
SCHEMBL6935130 0.72 OPRD1 (0.67) CYP1A2CYP3A4CYP2C9HPGDOPRM1
SCHEMBL6935555 0.72 OPRD1 (0.67) CYP1A2CYP3A4CYP2C9HPGDOPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0983251-B1 ANTI-INFLAMMATORY PIPERAZINYL-BENZYL-TETRAZOLE DERIVATIVES AND INTERMEDIATES THEREOF PFIZER LTD (GB) 2004-06-23 EP disclosed
US-6514975-B1 Tetrazoles as selective agonists for the delta opioid receptor PFIZER INC 2003-02-04 US disclosed