Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 12/20 | 0.43 |
| ▸ | CASP3 | P42574 | 5/20 | 0.40 |
| ▸ | CTSB | P07858 | 4/20 | 0.39 |
| ▸ | CTSL | P07711 | 3/20 | 0.39 |
| ▸ | CTSK | P43235 | 3/20 | 0.39 |
| ▸ | CASP7 | P55210 | 3/20 | 0.39 |
| ▸ | CASP8 | Q14790 | 2/20 | 0.39 |
| ▸ | IL1B | P01584 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4555747 | 0.91 | CASP1 (0.46) | CASP1CASP3CASP7CASP8IL1B | |
| SCHEMBL6054156 | 0.90 | CASP1 (0.43) | CASP1CTSBCTSLCTSKIL1B | |
| SCHEMBL4556632 | 0.87 | CASP1 (0.50) | CASP1CASP3CASP8 | |
| SCHEMBL4555306 | 0.83 | CASP1 (0.43) | CASP1CASP3 | |
| SCHEMBL1897510 | 0.81 | CASP1 (0.41) | CASP1CASP3CTSBCTSLCTSK | |
| SCHEMBL6054160 | 0.79 | PTGES (0.37) | CASP1 | |
| SCHEMBL1896555 | 0.79 | CASP1 (0.39) | CASP1CASP3CASP7CASP8 | |
| SCHEMBL4555732 | 0.78 | CASP1 (0.46) | CASP1CASP3CASP8 | |
| SCHEMBL5669625 | 0.78 | CASP1 (0.39) | CASP1CASP3CASP7CASP8 | |
| SCHEMBL6054176 | 0.78 | CASP1 (0.49) | CASP1CASP3CASP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091930-B1 | C-TERMINAL MODIFIED OXAMYL DIPEPTIDES AS INHIBITORS OF THE ICE/ced-3 FAMILY OF CYSTEINE PROTEASES | IDUN PHARMACEUTICALS INC (US) | 2006-12-13 | — | — | EP | claimed |
| US-6544951-B2 | Antiinflammatory agents; autoimmune diseases, nervous system degradation | IDUN PHARMACEUTICALS, INC. | 2003-04-08 | — | — | US | claimed |
| US-20090214527-A1 | Combination Of Anti-Madcam Antibody And Antifibrotic Caspase Inhibitor To Treat Liver Fibrosis | BURGESS GARY | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090214527-A1 | Combination Of Anti-Madcam Antibody And Antifibrotic Caspase Inhibitor To Treat Liver Fibrosis | CASP5, ADAM17, CASP1 | CASP1 3/4885CASP3 24/4885CTSB 63/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.