Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4570534 | 0.85 | MAOB (0.47) | POLBNPC1RAB9ASMN1; SMN2MRGPRX4 | |
| SCHEMBL17770539 | 0.84 | MRGPRX4 (0.67) | POLBNPC1RAB9ASMN1; SMN2MRGPRX4 | |
| SCHEMBL9356634 | 0.80 | POLB (0.55) | POLBNPC1RAB9ASMN1; SMN2MRGPRX4 | |
| SCHEMBL1950961 | 0.80 | MRGPRX4 (0.54) | POLBNPC1RAB9ASMN1; SMN2MRGPRX4 | |
| SCHEMBL21679225 | 0.79 | RAB9A (0.54) | POLBNPC1RAB9ASMN1; SMN2MRGPRX4 | |
| SCHEMBL4868587 | 0.77 | AKR1C4 (0.58) | POLBKDM4EMEN1KMT2AMAPT | |
| SCHEMBL24977302 | 0.76 | KMT2A (0.52) | POLBNPC1RAB9ASMN1; SMN2MRGPRX4 | |
| SCHEMBL22160247 | 0.76 | RAB9A (0.68) | POLBNPC1RAB9ASMN1; SMN2MRGPRX4 | |
| SCHEMBL9356550 | 0.75 | POLB (0.52) | POLBNPC1RAB9ASMN1; SMN2MRGPRX4 | |
| SCHEMBL1388037 | 0.75 | RXRA (0.60) | POLBNPC1RAB9ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125728-A1 | NOVEL COMBINATION OF COMPOUNDS TO BE USED IN THE TREATMENT OF AIRWAY DISEASES, ESPECIALLY CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) AND ASTHMA | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008103125-A1 | NOVEL COMBINATION OF COMPOUNDS TO BE USED IN THE TREATMENT OF AIRWAY DISEASES, ESPECIALLY CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) AND ASTHMA | ASTRAZENECA AB (SE) | 2008-08-28 | — | — | WO | disclosed |