Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.46 |
| ▸ | CLK1 | P49759 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.45 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5673498 | 0.76 | SMN1; SMN2 (0.36) | PDGFRBALDH1A1SMN1; SMN2MEN1KMT2A | |
| Nortopsentin D SCHEMBL29489921 | 0.72 | PDGFRB (0.62) | PDGFRBMAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL4398433 | 0.71 | MAPT (0.62) | PDGFRBMAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL13624863 | 0.71 | PDGFRB (0.60) | PDGFRBMAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL3676456 | 0.71 | SLC6A4 (0.63) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL25034150 | 0.70 | TUBB4A (0.68) | PDGFRBMAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL15064538 | 0.69 | SMN1; SMN2 (0.43) | PDGFRBMAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL4861987 | 0.69 | GSK3B (0.43) | MAPTRAB9AGSK3BLMNACYP1A2 | |
| SCHEMBL4400158 | 0.68 | PDGFRB (0.56) | PDGFRBMAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL25034151 | 0.68 | PDGFRB (1.00) | PDGFRBMAPTALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2613630-A1 | HYDROGEN BOND FORMING FLUORO KETOLIDES FOR TREATING DISEASES | Cempra Pharmaceuticals, Inc. (US) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012034058-A1 | HYDROGEN BOND FORMING FLUORO KETOLIDES FOR TREATING DISEASES | CEMPRA PHARMACEUTICALS, INC. (US) | 2012-03-15 | — | — | WO | disclosed |