Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | STK17A | Q9UEE5 | 4/20 | 0.36 |
| ▸ | ESR1 | P03372 | 5/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.36 |
| ▸ | SYK | P43405 | 4/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | STK17B | O94768 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 2/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4556286 | 0.93 | ESR1 (0.36) | ESR1ESR2PIM1CDC7CSNK2A2 | |
| SCHEMBL3333095 | 0.82 | PIM1 (0.54) | ALDH1A1MEN1HPGDKMT2AHSD17B10 | |
| SCHEMBL4555662 | 0.76 | VCP (0.38) | ESR1ESR2 | |
| SCHEMBL3329659 | 0.75 | PIM1 (0.56) | ALDH1A1HPGDHSD17B10ESR1ESR2 | |
| SCHEMBL4555954 | 0.74 | SYK (0.46) | SYKKDRKCNH2AURKB | |
| SCHEMBL29145926 | 0.71 | ALDH1A1 (0.45) | ALDH1A1MEN1HPGDKMT2AHSD17B10 | |
| SCHEMBL25856355 | 0.71 | IDO1 (0.46) | ALDH1A1ESR1ESR2 | |
| SCHEMBL22735015 | 0.67 | PIM1 (0.59) | ALDH1A1MEN1HPGDKMT2AESR1 | |
| SCHEMBL11604188 | 0.67 | ALDH1A1 (0.53) | ALDH1A1MEN1HPGDKMT2AESR1 | |
| SCHEMBL5809528 | 0.67 | ALDH1A1 (0.67) | ALDH1A1ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074103-A1 | 6-PHENYLPYRIMIDINONES AS PIM MODULATORS | Exelixis, Inc. (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008133955-A1 | 6-PHENYLPYRIMIDINONES AS PIM MODULATORS | EXELIXIS, INC. (US) | 2008-11-06 | — | — | WO | disclosed |