Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 9/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 8/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.35 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.35 |
| ▸ | HSD17B14 | Q9BPX1 | 2/20 | 0.34 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.34 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4557013 | 0.93 | ALDH1A1 (0.38) | ESR1ESR2PIM1CDC7CSNK2A2 | |
| SCHEMBL3329659 | 0.81 | PIM1 (0.56) | ESR1ESR2PIM1CDC7CSNK2A2 | |
| SCHEMBL25856355 | 0.78 | IDO1 (0.46) | ESR1ESR2 | |
| SCHEMBL4555662 | 0.78 | VCP (0.38) | ESR1ESR2 | |
| SCHEMBL3333095 | 0.75 | PIM1 (0.54) | ESR1ESR2PIM1CDC7CSNK2A2 | |
| SCHEMBL4555954 | 0.75 | SYK (0.46) | — | |
| SCHEMBL29145926 | 0.70 | ALDH1A1 (0.45) | ESR1ESR2 | |
| SCHEMBL22735015 | 0.69 | PIM1 (0.59) | ESR1ESR2PIM1CDC7CSNK2A2 | |
| SCHEMBL11637154 | 0.67 | TUBB4A (0.47) | HSD17B2 | |
| SCHEMBL28698738 | 0.66 | PDE10A (0.47) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074103-A1 | 6-PHENYLPYRIMIDINONES AS PIM MODULATORS | Exelixis, Inc. (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008133955-A1 | 6-PHENYLPYRIMIDINONES AS PIM MODULATORS | EXELIXIS, INC. (US) | 2008-11-06 | — | — | WO | disclosed |