Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 10/20 | 0.54 |
| ▸ | TTK | P33981 | 2/20 | 0.38 |
| ▸ | PLK1 | P53350 | 2/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.38 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 2/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11340779 | 0.77 | IGF1R (0.72) | IGF1R | |
| SCHEMBL4077928 | 0.72 | NTRK1 (0.49) | IGF1RPLK1 | |
| SCHEMBL23217059 | 0.70 | NTRK1 (0.52) | IGF1R | |
| SCHEMBL30010123 | 0.70 | NTRK1 (0.52) | IGF1R | |
| SCHEMBL4469628 | 0.70 | ADORA2A (0.41) | — | |
| SCHEMBL4466340 | 0.69 | IGF1R (0.50) | IGF1RMERTK | |
| SCHEMBL4557950 | 0.66 | IGF1R (0.59) | IGF1RTTKCCNA2CDK2EGFR | |
| SCHEMBL30782745 | 0.66 | HRH4 (0.40) | — | |
| SCHEMBL5030706 | 0.65 | GBA1 (0.51) | TTK | |
| SCHEMBL15256312 | 0.65 | IGF1R (0.56) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |