Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.57 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | ALPL | P05186 | 9/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | FABP4 | P15090 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364604 | 0.81 | CA12 (0.59) | CYP19A1CA12CA9MEN1KMT2A | |
| SCHEMBL1940847 | 0.77 | PKM (0.55) | CYP19A1CA12CA9ALPLMEN1 | |
| SCHEMBL30753799 | 0.77 | PKM (0.55) | CYP19A1CA12CA9ALPLMEN1 | |
| SCHEMBL14851521 | 0.76 | FABP4 (0.78) | CA12CA9LMNAFABP4HTT | |
| SCHEMBL13788806 | 0.75 | CA12 (0.54) | CYP19A1CA12CA9ALPLMEN1 | |
| SCHEMBL18546034 | 0.74 | CYP19A1 (0.73) | CYP19A1ALPLMEN1KMT2ALMNA | |
| SCHEMBL23847019 | 0.73 | MEN1 (0.61) | CA12CA9ALPLMEN1KMT2A | |
| SCHEMBL3761698 | 0.73 | ALPL (0.72) | CA12CA9ALPLMEN1KMT2A | |
| SCHEMBL7578214 | 0.73 | USP2 (0.73) | ALPLMEN1KMT2ALMNAALOX12 | |
| SCHEMBL12347508 | 0.73 | CA12 (0.51) | CYP19A1CA12CA9ALPLMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940397-A2 | METHODS FOR TREATING HYPERTENSION | Tap Pharmaceutical Products, Inc. (US) | 2008-07-09 | — | — | EP | claimed |
| WO-2007019153-A2 | METHODS FOR TREATING HYPERTENSION | TAP PHARMACEUTICAL PRODUCTS, INC. (US) | 2007-02-15 | — | — | WO | claimed |
| EP-2120956-A1 | METHODS FOR PREVENTING OR REDUCING THE NUMBER OF GOUT FLARES USING XANTHINE OXIDOREDUCTASE INHIBITORS AND ANTI-INFLAMMATORY AGENTS | Takeda Pharmaceuticals North America (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008089296-A1 | METHODS FOR PREVENTING OR REDUCING THE NUMBER OF GOUT FLARES USING XANTHINE OXIDOREDUCTASE INHIBITORS AND ANTI-INFLAMMATORY AGENTS | TAKEDA PHARMACEUTICALS NORTH AMERICA (US) | 2008-07-24 | — | — | WO | disclosed |
| EP-1940397-A2 | METHODS FOR TREATING HYPERTENSION | Tap Pharmaceutical Products, Inc. (US) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007019153-A2 | METHODS FOR TREATING HYPERTENSION | TAP PHARMACEUTICAL PRODUCTS, INC. (US) | 2007-02-15 | — | — | WO | disclosed |