Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | GRM5 | P41594 | 6/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | GBA1 | P04062 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30509648 | 0.79 | RAB9A (0.72) | RAB9AKMT2AMEN1GRM5NPC1 | |
| SCHEMBL5034141 | 0.79 | RAB9A (0.72) | RAB9AKMT2AMEN1GRM5NPC1 | |
| SCHEMBL30070833 | 0.79 | KMT2A (0.72) | RAB9AKMT2AMEN1GRM5NPC1 | |
| SCHEMBL2483166 | 0.79 | KMT2A (0.72) | RAB9AKMT2AMEN1GRM5NPC1 | |
| SCHEMBL28048829 | 0.77 | RAB9A (0.50) | RAB9AKMT2AMEN1NPC1MAPT | |
| SCHEMBL11524092 | 0.76 | KMT2A (0.68) | RAB9AKMT2AMEN1GRM5NPC1 | |
| SCHEMBL14353530 | 0.75 | RAB9A (1.00) | RAB9AKMT2AMEN1GRM5NPC1 | |
| SCHEMBL3119185 | 0.75 | RAB9A (0.78) | RAB9AKMT2AMEN1GRM5NPC1 | |
| SCHEMBL31725239 | 0.75 | RAB9A (0.78) | RAB9AKMT2AMEN1GRM5NPC1 | |
| SCHEMBL49953 | 0.73 | RAB9A (0.75) | RAB9AKMT2AMEN1GRM5NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009155565-A1 | TRIAZOLOPYRIDINE JAK INHIBITOR COMPOUNDS AND METHODS | GENENTECH, INC. (US) | 2009-12-23 | — | — | WO | disclosed |