SCHEMBL4558248

SCHEMBL4558248

NC(=O)N(Sc1ccccc1)Sc1ccccc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIRT1 Q96EB6 1/20 0.42
MAPT P10636 4/20 0.41
CYP3A4 P08684 2/20 0.41
CYP2C19 P33261 2/20 0.41
HSD17B10 Q99714 2/20 0.41
POLB P06746 1/20 0.41
PARP1 P09874 1/20 0.41
TSHR P16473 1/20 0.41
RECQL P46063 1/20 0.41
BLM P54132 1/20 0.41
PMP22 Q01453 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
FFAR1 O14842 1/20 0.40
ALOX5 P09917 2/20 0.38
HPGD P15428 3/20 0.36
ALDH1A1 P00352 3/20 0.36
CYP1A2 P05177 1/20 0.36
CYP2D6 P10635 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28759912 0.88 ALOX5 (0.38) SIRT1MAPTCYP3A4CYP2C19HSD17B10
SCHEMBL6686036 0.83 SIRT1 (0.40) SIRT1MAPTCYP3A4CYP2C19HSD17B10
SCHEMBL7079000 0.82 CYP3A4 (0.46) SIRT1MAPTCYP3A4CYP2C19HSD17B10
SCHEMBL7078994 0.78 CYP3A4 (0.43) SIRT1MAPTCYP3A4CYP2C19HSD17B10
SCHEMBL2981447 0.78 SCN2A (0.40) SIRT1MAPTCYP3A4CYP2C19HSD17B10
SCHEMBL3077752 0.78 SIRT1 (0.37) SIRT1MAPTCYP3A4CYP2C19HSD17B10
SCHEMBL19664731 0.77 HPGD (0.45) MAPTHSD17B10FFAR1HPGDALDH1A1
SCHEMBL3068028 0.75 BLM (0.40) SIRT1MAPTCYP3A4CYP2C19HSD17B10
SCHEMBL28268677 0.74 FFAR1 (0.38) SIRT1MAPTCYP3A4CYP2C19HSD17B10
SCHEMBL9665436 0.74 SMN1; SMN2 (0.41) SIRT1MAPTHSD17B10TSHRFFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023099848-A1 FOAMING COMPOSITION COMPATIBLE WITH STEEL FOR THE ASSISTED RECOVERY OF HYDROCARBONS ARKEMA FRANCE (FR) 2023-06-08 WO claimed
EP-0382425-B1 Optical recording medium JUJO PAPER CO LTD (JP) 1994-06-22 EP claimed
US-5079304-A Curable ZEON CHEMICALS U.S.A., INC. (US) 1992-01-07 US claimed
EP-0083075-B1 COLOUR DEVELOPING SHEET FOR A PRESSURE-SENSITIVE RECORDING SHEET JUJO PAPER CO., LTD. (JP) 1986-08-13 EP claimed
US-20240116863-A1 DIPHENYL THIOUREA AND DIPHENYL UREA DERIVATIVES AS INHIBITORS OF ENDOCYTOSIS Indian Institute of Science Education and Research, Mohali (IISER Mohali) (IN) 2024-04-11 US disclosed
US-20240116863-A1 DIPHENYL THIOUREA AND DIPHENYL UREA DERIVATIVES AS INHIBITORS OF ENDOCYTOSIS Indian Institute of Science Education and Research, Mohali (IISER Mohali) (IN) 2024-04-11 US disclosed
WO-2024062191-A1 GAS-PHASE COMPOSITION FOR INHIBITING CORROSION EXPOSED TO CONDENSED WATER ARKEMA FRANCE (FR) 2024-03-28 WO disclosed
US-20230375937-A1 SUBSTRATE PROCESSING COMPOSITION AND SUBSTRATE PROCESSING METHOD USING THE SAME SK INC. (KR) 2023-11-23 US disclosed
WO-2023099848-A1 FOAMING COMPOSITION COMPATIBLE WITH STEEL FOR THE ASSISTED RECOVERY OF HYDROCARBONS ARKEMA FRANCE (FR) 2023-06-08 WO disclosed
CN-112746293-A Copper alkaline bright cleaning agent and preparation method thereof 盐城市科瑞达科技咨询服务有限公司 2021-05-04 CN disclosed
CN-111058065-A Composite electroplating brightener and preparation method thereof 浙江金欣新材料科技股份有限公司 2020-04-24 CN disclosed
CN-107930602-A A kind of clean operating room in hospital purificant 安徽省伟业净化设备有限公司 2018-04-20 CN disclosed
WO-2008074962-A2 MASTER BLENDS INCLUDING AN ETHYLENE AND ALPHA-OLEFINE COPOLYMER AS A CARRIER AND CONTAINING VULCANISATION AGENTS MLPC INTERNATIONAL (FR) 2008-06-26 WO disclosed
EP-1275693-B1 IMPACT MODIFIER, PROCESS FOR PRODUCING THE SAME, AND THERMOPLASTIC RESIN COMPOSITION CONTAINING THE SAME MITSUBISHI RAYON CO (JP) 2006-01-11 EP disclosed
US-6833409-B2 Graft-polymerizing a polyalkyl (meth)acrylate with a vinyl monomer and a compound which has a sulfonic or sulfuric acid group each having a different glass transition temperature MITSUBISHI RAYON CO., LTD. (JP) 2004-12-21 US disclosed
US-20030114588-A1 Impact modifier, process for producing the same, and thermoplastic resin composition containing the same MITSUBISHI CHEMICAL CORPORATION (JP) 2003-06-19 US disclosed
EP-1275693-A1 IMPACT MODIFIER, PROCESS FOR PRODUCING THE SAME, AND THERMOPLASTIC RESIN COMPOSITION CONTAINING THE SAME Mitsubishi Rayon Co., Ltd. (JP) 2003-01-15 EP disclosed
WO-1994025253-A1 SHORT-FIBER-REINFORCED PLASTIC FOILS SIKA AG, VORM. KASPAR WINKLER & CO. (CH) 1994-11-10 WO disclosed
US-4321092-A CONTAINING A COLOR ACCEPTING METAL CHLORIDE, UREA, THIOUREA OR DIPHENYLTHIOUREA KORES HOLDING ZUG AG (CH) 1982-03-23 US disclosed
US-4082711-A COELASTOMER, PLASTICIZING HOECHST AKTIENGESELLSCHAFT (DT) 1978-04-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240116863-A1 DIPHENYL THIOUREA AND DIPHENYL UREA DERIVATIVES AS INHIBITORS OF ENDOCYTOSIS SLC14A1, PKD1, PKD2 SIRT1 3859/4885MAPT 436/4885CYP3A4 2872/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.