Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 10/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 10/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 9/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.37 |
| ▸ | LMNA | P02545 | 6/20 | 0.37 |
| ▸ | TSHR | P16473 | 6/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HBB | P68871 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 5/20 | 0.35 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10852266 | 0.83 | FDPS (0.51) | FDPSHDAC1HDAC6LTA4HCYP1A2 | |
| SCHEMBL1079073 | 0.83 | FDPS (0.50) | FDPSHDAC1HDAC6LTA4HCYP1A2 | |
| SCHEMBL4592188 | 0.80 | FDPS (0.51) | FDPSHDAC1HDAC6LTA4HCYP1A2 | |
| SCHEMBL28615898 | 0.79 | AHCY (0.55) | FDPSHDAC1HDAC6LTA4HCYP1A2 | |
| SCHEMBL6005045 | 0.79 | FDPS (0.50) | FDPSHDAC1HDAC6LTA4HCYP1A2 | |
| SCHEMBL9516044 | 0.77 | FDPS (0.59) | FDPSHDAC1HDAC6LTA4HCYP1A2 | |
| SCHEMBL9597540 | 0.77 | FDPS (0.55) | FDPSHDAC1HDAC6LTA4HCYP1A2 | |
| SCHEMBL6125409 | 0.77 | FDPS (0.54) | FDPSHDAC1HDAC6LTA4HCYP1A2 | |
| SCHEMBL5062453 | 0.77 | FDPS (0.54) | FDPSHDAC1HDAC6LTA4HCYP1A2 | |
| SCHEMBL28817988 | 0.77 | FDPS (0.54) | FDPSHDAC1HDAC6LTA4HCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090233948-A1 | Inhibitors of nucleoside phosphorylases and nucleosidases | NATIONAL INSTITUTES OF HEALTH | 2009-09-17 | — | — | US | claimed |
| EP-1881984-A1 | INHIBITORS OF NUCLEOSIDE PHOSPHORYLASES AND NUCLEOSIDASES | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY, a division of YESHIVA UNIVERSITY (US) | 2008-01-30 | — | — | EP | claimed |
| WO-2006123953-A1 | INHIBITORS OF NUCLEOSIDE PHOSPHORYLASES AND NUCLEOSIDASES | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2006-11-23 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233948-A1 | Inhibitors of nucleoside phosphorylases and nucleosidases | PNP, MTAP, TYMP | FDPS 371/4885HDAC1 1295/4885HDAC6 1976/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.